GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2076028 | 1 | rs138702 | chr22:39132601 | TOMM22 | chr22:39077954-39080763:+ | 0.11 | 3.81 | 0.000149 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs138712 | chr22:39141600 | LOC646851 | chr22:38974125-39052634:- | 0.16 | 4.71 | 2.75E-6 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs138713 | chr22:39142615 | LOC646851 | chr22:38974125-39052634:- | 0.14 | 4.16 | 3.44E-5 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs138716 | chr22:39146527 | LOC646851 | chr22:38974125-39052634:- | 0.14 | 3.91 | 9.88E-5 | Resting heart rate |
| BRCA | cis | rs2857891 | 1 | rs1388527 | chr11:6948441 | ZNF215 | chr11:6947654-7005861:+ | -0.32 | -6.72 | 2.89E-11 | Response to cytadine analogues (cytosine arabinoside) |
| BRCA | cis | rs2243480 | 1 | rs1392104 | chr7:65759107 | CCT6P1 | chr7:65216092-65228661:+ | -0.29 | -6.23 | 6.55E-10 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs1392104 | chr7:65759107 | CRCP | chr7:65579805-65619551:+ | 0.22 | 3.79 | 0.000157 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs1392104 | chr7:65759107 | LOC493754 | chr7:65993446-66057363:- | -0.21 | -3.57 | 0.000377 | Diabetic kidney disease |
| BRCA | cis | rs877529 | 1 | rs139388 | chr22:39531732 | APOBEC3H | chr22:39493290-39500070:+ | -0.12 | -5.51 | 4.52E-8 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139396 | chr22:39538485 | APOBEC3H | chr22:39493290-39500070:+ | -0.12 | -5.14 | 3.33E-7 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139401 | chr22:39546074 | APOBEC3H | chr22:39493290-39500070:+ | -0.12 | -5.57 | 3.31E-8 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139402 | chr22:39546145 | APOBEC3H | chr22:39493290-39500070:+ | -0.13 | -5.71 | 1.5E-8 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139404 | chr22:39547201 | APOBEC3H | chr22:39493290-39500070:+ | -0.12 | -5.43 | 7.0E-8 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139413 | chr22:39553772 | APOBEC3H | chr22:39493290-39500070:+ | 0.11 | 4.78 | 1.99E-6 | Multiple myeloma |
| BRCA | cis | rs877529 | 1 | rs139413 | chr22:39553772 | SYNGR1 | chr22:39745954-39781591:+ | -0.11 | -3.5 | 0.00049 | Multiple myeloma |